Knowledge Centre

Scientific updates

Calm summaries of established medical developments, with source links and what each update means for you as a patient.

Keto foods like avocado, eggs, cheese and nuts beside fruit and bread
Scientific updates
Published: 7 October 2026 11 min read Dr. Youssef Hagag (Physician and Medical Researcher in Clinical Nutrition)

Science update: What Does the Evidence Say About Keto Benefits and Risks?

Keto may support short-term weight loss for some people, but evidence does not prove lasting superiority for everyone. Learn the risks, the difference between ketosis and ketoacidosis, and who needs clinical supervision.

Medical sources

  1. Kun X et al. Comparative effects of ketogenic diets and mediterranean diets on obesity and metabolic outcomes: a systematic review and meta-analysis.
  2. Żurawski T, Bartosiewicz A. Do Ketogenic Diets Produce Greater Weight Loss than Higher-Carbohydrate Diets Under Comparable Prescribed Energy Conditions? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
  3. Patikorn C et al. Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials.
  4. Schopf C et al. Adverse events and tolerability of ketogenic diets - a systematic literature analysis.
  5. Acharya P et al. Incidence and Characteristics of Kidney Stones in Patients on Ketogenic Diet: A Systematic Review and Meta-Analysis.
  6. Kirkpatrick CF et al. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate diets for the management of body weight and other cardiometabolic risk factors.
  7. US Food and Drug Administration. FARXIGA (dapagliflozin) prescribing information, 2026.
  8. NHS. Diabetic ketoacidosis.
  9. Cucuzzella M et al. Adapting Medication for Type 2 Diabetes to a Low Carbohydrate Diet.
  10. de Amorim ALB et al. Carbohydrate restriction during lactation: A systematic review.
  11. Cervenka MC et al. International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies.
  12. Lichtenstein AH et al. 2026 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association.
  13. StatPearls. The Ketogenic Diet: Clinical Applications, Evidence-based Indications, and Implementation.
Learn more: Science update: What Does the Evidence Say About Keto Benefits and Risks?
A blister pack of tablets beside eggs, salmon, milk and yogurt
Scientific updates
Published: 7 October 2026 11 min read Dr. Youssef Hagag (Physician and Medical Researcher in Clinical Nutrition)

Science update: Metformin and vitamin B12, who needs testing and when?

The ADA Standards of Care in Diabetes—2026 advise considering periodic vitamin B12 assessment during long-term metformin use, especially with anaemia or neuropathy. Learn who may need testing, why numbness has more than one possible cause, and how treatment is selected without stopping metformin or taking injections at random.

Medical sources

  1. American Diabetes Association Professional Practice Committee for Diabetes. 3. Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes—2026.
  2. American Diabetes Association Professional Practice Committee for Diabetes. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes—2026.
  3. American Diabetes Association Professional Practice Committee for Diabetes. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2026.
  4. UK Medicines and Healthcare products Regulatory Agency. Metformin and reduced vitamin B12 levels: new advice for monitoring patients at risk.
  5. NICE. Vitamin B12 deficiency in over 16s: diagnosis and management (NG239), recommendations.
  6. NIH Office of Dietary Supplements. Vitamin B12: Fact Sheet for Health Professionals.
  7. Aroda VR et al. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study.
  8. de Jager J et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.
  9. Pratama S et al. The efficacy of vitamin B12 supplementation for treating vitamin B12 deficiency and peripheral neuropathy in metformin-treated type 2 diabetes mellitus patients: A systematic review.
  10. Obeid R et al. Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus.
  11. NHS. Vitamin B12 or folate deficiency anaemia.
  12. Harrington DJ et al. The application and interpretation of laboratory biomarkers for the evaluation of vitamin B12 status.
Learn more: Science update: Metformin and vitamin B12, who needs testing and when?
Fresh whole foods on one side and wrapped processed snacks on the other
Scientific updates
Published: 7 October 2026 9 min read Dr. Youssef Hagag (Physician and Medical Researcher in Clinical Nutrition)

Science update: What Does New Evidence Say About Ultra-Processed Foods?

The 2025 Lancet Series brought together evidence on ultra-processed foods and health. Learn what the category means, where the evidence is limited, and how to make realistic swaps without fear.

Medical sources

Learn more: Science update: What Does New Evidence Say About Ultra-Processed Foods?
A sunny morning balcony table with tea, eggs, sardines and milk
Scientific updates
Published: 7 October 2026 10 min read Dr. Youssef Hagag (Physician and Medical Researcher in Clinical Nutrition)

Science update: Vitamin D Testing Is Not Routine for Everyone

The Endocrine Society's 2024 guideline changed how routine vitamin D testing is viewed in healthy people. Learn who does not need screening and who may still need testing for a clinical reason.

Medical sources

Learn more: Science update: Vitamin D Testing Is Not Routine for Everyone
A doctor's desk with a stethoscope, a printed document, a laptop and a plant
Scientific updates
Published: 7 October 2026 10 min read Dr. Youssef Hagag (Physician and Medical Researcher in Clinical Nutrition)

Science update: What WHO's GLP-1 obesity guideline actually recommends

In December 2025, WHO issued its first global guideline on GLP-1 therapies for obesity in adults. Learn who it covers, why both recommendations are conditional, and their evidence certainty.

Medical sources

Learn more: Science update: What WHO's GLP-1 obesity guideline actually recommends
Article illustration: Responsive complementary feeding: follow the baby, do not force
Article illustration: Biotin before blood tests: why the laboratory needs to know
Article illustration: Diabetes review: beyond HbA1c
Article illustration: Non-surgical body contouring safety: modalities, risks and contraindications
Scientific updates
Published: 31 August 2026 9 min read Dr. Shimaa Fouad

Non-surgical body contouring safety: modalities, risks and contraindications

Body contouring is a cosmetic procedure, not an obesity treatment. Learn the safety profiles of 5 cleared modalities, paradoxical hyperplasia, and key contraindications.

Medical sources

  1. US Food and Drug Administration (FDA). Non-Invasive Body Contouring Technologies. 2024.
  2. Mazzoni D, Lin MJ, Dubin DP, Khorasani H. Review of non-invasive body contouring devices for fat reduction, skin tightening and muscle definition. Australas J Dermatol. 2019;60(4):278-283.
  3. Mah AE, Razeghi P, Li C, et al. Incidence of Paradoxical Adipose Hyperplasia After Cryolipolysis: A Systematic Review and Meta-Analysis. Aesthet Surg J Open Forum. 2025;7:ojaf001.
  4. Lim et al. FDA MAUDE Database Reported Adverse Events on Noninvasive Body Contouring, Cellulite Treatment, and Muscle Stimulation from 2015 to 2021. Dermatol Surg. 2022.
  5. National Institute for Health and Care Excellence (NICE). Overweight and obesity management (NICE guideline NG246). 2023.
  6. Alizadeh Z, Halabchi F, Mazaheri R, Abolhasani M, Tabesh M. Review of the Mechanisms and Effects of Noninvasive Body Contouring Devices on Cellulite and Subcutaneous Fat. Int J Endocrinol Metab. 2016;14(4):e36727.
  7. Wulkan AJ, Vazirnia A, Avram MM. Complications With Noninvasive Fat and Cellulite Reduction Devices: A Cross-sectional Analysis of the US Food and Drug Administration Manufacturer and User Facility Device Experience Database. Dermatol Surg. 2022;48(7):727-732.
  8. Hedayati B, Juhasz M, Chu S, Mesinkovska NA. Adverse Events Associated With Cryolipolysis: A Systematic Review of the Literature. Dermatol Surg. 2020;46(Suppl 1):S8-S15.
  9. Kohan J, Vyas K, Erotocritou M, et al. High-Intensity Focused Electromagnetic (HIFEM) Energy With and Without Radiofrequency for Noninvasive Body Contouring: A Systematic Review. Aesthetic Plast Surg. 2024;48(5):915-926.
  10. Friedmann DP, Kommera J, Durga P, et al. Evaluating Real-world Use and Adverse Events From 3262 Patients Treated With 18,203 Cycles of Cryolipolysis for Localized Fat Reduction: A Multilocation Practice Retrospective Chart Review. Aesthet Surg J. 2025;45(5):512-521.
  11. Mysore V, Deepthi M, Chandrashekar BS, et al. Standard operating protocol for utilizing energy-based devices in aesthetic practice. J Cosmet Dermatol. 2024;23(12):3974-3987.
  12. Lin F, Vachiramon V, Casabona G, et al. Microfocused Ultrasound With Visualization for Body Indications: A Global Expert Consensus on Best Practices for Treatment of the Abdomen and Arms. J Cosmet Dermatol. 2025;24(10):3450-3461.
Learn more: Non-surgical body contouring safety: modalities, risks and contraindications
Article illustration: Scientific update: obesity care goes beyond BMI
Scientific updates
Published: 29 August 2026 7 min read Dr. Shimaa Fouad

Scientific update: obesity care goes beyond BMI

The new definition of clinical obesity and NICE guidance place waist size, organ function and related disease at the centre of decisions instead of reducing care to a BMI number. Learn what this changes in assessment and treatment.

Medical sources

Learn more: Scientific update: obesity care goes beyond BMI
Article illustration: Assessing muscle mass and strength in nutrition care
Article illustration: Dietary supplements should be targeted, not automatic
Article illustration: Vitamin B12 for plant-based eating: plan a reliable source
Article illustration: Scientific update: appetite-regulating weight medicines are not one short course for everyone
Scientific updates
Published: 24 August 2026 7 min read Dr. Shimaa Fouad

Scientific update: appetite-regulating weight medicines are not one short course for everyone

Medical weight treatment may be long term, and the STEP 1 and SURMOUNT-4 trials show that regain after stopping is a biological response, not a failure of willpower. Learn when the plan is reviewed and how to prepare for stopping.

Medical sources

Learn more: Scientific update: appetite-regulating weight medicines are not one short course for everyone
Article illustration: Scientific update: movement has health benefits even when the scale barely changes
Scientific updates
Published: 23 August 2026 7 min read Dr. Shimaa Fouad

Scientific update: movement has health benefits even when the scale barely changes

Activity is not judged by weight alone: fitness, heart, glucose, liver, sleep, mood and muscle all benefit from regular movement, even when the scale stays still.

Medical sources

Learn more: Scientific update: movement has health benefits even when the scale barely changes
Article illustration: Mesotherapy gone wrong: safety, warning signs and what to do
Article illustration: High blood pressure: why a pattern of readings matters
Article illustration: Type 2 diabetes remission is not a permanent cure
Article illustration: Coeliac testing before a gluten-free diet: why order matters
Article illustration: Fatty liver or fibrosis? What ultrasound can say and what comes next
Article illustration: Scientific update: silent gallstones usually do not need treatment
Article illustration: Scientific update: repeated safety questions before surgery are deliberate
Article illustration: Multidisciplinary bariatric assessment: what each team member reviews
Article illustration: Lifelong bariatric follow-up: why it continues after weight loss
Article illustration: Acne needs gentle care, not aggressive scrubbing
Article illustration: Cellulite is a natural skin structure feature: causes, anatomy and treatment limits
Scientific updates
Published: 12 August 2026 9 min read Dr. Shimaa Fouad

Cellulite is a natural skin structure feature: causes, anatomy and treatment limits

Cellulite is a structural skin feature, not obesity. Learn how fibrous septae shape dimples, why it affects women predominantly, and what clinical treatments offer.

Medical sources

Learn more: Cellulite is a natural skin structure feature: causes, anatomy and treatment limits
Article illustration: Scientific update: a child’s growth is a trajectory, not a single comparison
Article illustration: Ultrasound: sound waves, but a defined clinical question
Article illustration: Normal abdominal ultrasound but pain continues: what the result means and what comes next

Knowledge Centre

How La Rose reviews Knowledge Centre content

Every published entry identifies its publication date, listed author and reviewer where available, and linked medical sources. Each full entry includes a publication record so readers can see recorded information without us guessing an unrecorded update date.

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